ABSTRACT
Introduction: COVID-19 is a problem for the humanity. Since now, 526.534.751 of confirmed cases. The world campain vaccination started in the end of 2020. Until now, we had almost 12 bilions people vaccinated. We never had in the world a massive vaccination campain like that. Considering that medications and vaccines can present adverse events, some cases of glomerulopathies were described. Case Description: We describe 50 yea-old white male patient who was obese and presented hypertension well controlled with Six months before admission, routine blood and urine tests were normal. He received two doses of Coronavac (Sinovac, China) inactivated virus vaccine for Covid-19 (28 day interval between dosses). On December 2021, he received a third dose (booster) Covid-19 vaccine from Pfizer-BioNtech (RNA). One day later, he began to experience high fever lasting one day, severe and progressively chest pain. The patient was hospitalized with pericarditis and AKI KDIGO 1. Corticosteroids and support measures were taken leading to an improvement in the cardiac condition. Two weeks later, renal function progressively worsened, and hematuria and proteinuria ensured. Investigation was negative for autoimmune diseases, serum levels C3 and C4 were normal, and viral serologies were negative. The creatinine level rised to 5 mg/dL (440 mmol/L). A pulse of 1 g methylprednisone was initiated for 3 days. Renal biopsy showed necrotizing glomerulonephritis, with fibrocellular crescents and immune paucity. Two doses of Rituximab 1g was added and prednisone 1 mg/kg and azathioprine were used as maintenance regimen. After 4 months of treatment, the patient presented partial recovery of renal function with a creatinine of 1.7 mg/dL (150 mmol/L). Discussion(s): Glomerulopathies related to Covid infection and vaccines are scarce. Rocatello et al reported 17 cases of post-vaccination glomerulopathies, most of which were of minimal change disease with no case of necrotizing pauci immune-negative being related. Few cases were reported with positive ANCA-related necrotizing GN, and in the present case the patient had all negative antibodies. A causal relationship cannot be stated, but with mass vaccination, cases of rare adverse effects must be monitored and reported to better clarify their mechanisms and evolution.
ABSTRACT
The aim of this study was to investigate the experience of the COVID-19 pandemic in the city of Natal, RN, considering the age group of patients affected by the disease and their possible comorbidities, through epidemiological indicators. Therefore, we took a retrospective approach of the numbers, highlighting the prevalence of COVID-19, from the confirmed cases in the year 2020 until the date of January 26, 2021. This is a study with a transversal methodology, of a qualitative and quantitative nature. Patient documents were sought in the Epidemiological Bulletin of the Public Health Secretariat (SESAP/RN), Central Laboratory (LACEN/RN), Kaggle - Coronavirus Brazil, Ministry of Health (MH) Department of Primary Care (DPC), National Registry of Health Facilities (NRHF), SUS Virtual Learning Environment at the Federal University of Rio Grande do Norte (AVASUS/UFRN), Google COVID-19 Community Mobility Reports, Inter-American Development Bank (IDB) in the Coronavirus Impact Panel. In Brazil there are already more than 9,834,513 confirmed cases and almost 239,245 thousand deaths (data collected until February 15, 2021) and in the state of Rio Grande do Norte (RN) there are 147,631 confirmed new cases and 3,381 deaths (data from February 15, 2021). The current scenario requires preventive actions of self-care and collective protection, so that, in this way, there is a reduction in the risks of the virus infecting people from the most vulnerable groups, but this requires the involvement of the mass population.
ABSTRACT
A world crisis was started when the World Health Organization (WHO) declared Covid-19 a pandemic. Executives at a natural gas pipeline carrier should implement a crisis management plan to deal with the situation. The present technical report aims to describe the steps taken in the management of the Covid-19 pandemic crisis in a gas pipeline transportation company, presenting the challenges faced in analyzing the scenario, making decisions amid the uncertainty of the moment and the impacts of decisions made on the strategic planning of the company and its workers. The direct participation of one of the authors in the crisis committee established allowed the production of the technical report according to Rojo's protocol (2014) according to the case study method. The results obtained with the proposed intervention went through the decision to operate remotely, with 100% of employees working from home. No interruption in the natural gas transportation service was recorded in the period. There were 4 cases of contamination among the 175 employees of the Company between March and June 2020, as well as 4 cases of contamination among 149 direct dependents. Neither an employee nor his dependent needed to be hospitalized for treatment and not one death was recorded. And the strategic actions planned for the year were maintained and carried out.